Sign in
Back
In-Vitro Anticancer Evaluation of Some Novel Thioureido-Benzensulfonamide Derivatives
Journal article   Open access  Peer reviewed

In-Vitro Anticancer Evaluation of Some Novel Thioureido-Benzensulfonamide Derivatives

Mostafa M Ghorab, Mansour S Alsaid, Mohammed S Al-Dosari, Marwa G El-Gazzar and Ahmed H Arbab
Molecules (Basel, Switzerland), Vol.21(4), pp.409-409
25/03/2016
DOI: https://doi.org/10.3390/molecules21040409
PMCID: PMC6274422
PMID: 27023509

Abstract

Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Cell Line, Tumor Cell Proliferation - drug effects Humans Sulfonamides - administration & dosage Sulfonamides - chemical synthesis Sulfonamides - chemistry Thiourea - chemistry
A novel series of sulfonamide derivatives (14 compounds) bearing thiourea moieties were efficiently synthesized and evaluated for their possible in vitro anticancer activity against four human tumor cell lines. The results indicated that compound 6 was the most potent, showing effectiveness on all the tested cell lines. Compounds 7 and 10 also showed promising results.
url
https://doi.org/10.3390/molecules21040409View
Published (Version of record) Open

Metrics

1 Record Views

Details