Abstract
A series of 11 new hydrazone-1,2,3-triazole hybrid molecules have been synthesized. All the synthesized compounds were confirmed by different analytical techniques and were evaluated for their antimicrobial activity. Most of the tested compounds were active against the Gram-positive bacterial strains, but resistant toward the two Gram-negative bacterial strains. Among the synthesized 4-nitrophenyl azide-based 1,2,3-triazole-hydrazone hybrids 7-17, 2-[{1-(4-nitrophenyl)-1H-1,2,3-triazol-4-yl}methoxy]-N'-{(furan-2-yl)methylene}benzohydrazide (14) possessed highest antibacterial potential against Gram-negative bacterial strains Escherichia coli and Klebsiella pneumoniae, better than the standard drug Amoxicillin. Fungal strain Candida albicans was resistant against most of the tested compounds. Compound 8 showed highest in silico absorption (96.57%), with low gastrointestinal absorption and also had good drug-likeness properties as per absorption, distribution, metabolism, and elimination prediction.
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