Abstract
In this paper, we investigate the effect of addition SrO for phosphate bioactive optical glasses (40P2O5–20Na2O–10Ca(OH)2–20CaCl2–8.0ZnO–2.0SrO, in mol%, labelled as BGSr) on antimicrobial activity, antiproliferative/cytotoxicity against normal and activated splenic cells in vitro. Moreover, the effect of BGSr on in vivo and in vitro cytotoxicity and in vitro effects of activated splenic cells were studied. It was observed that the optical BGSr glasses possess high antimicrobial and antifungal properties. A cytotoxic effect on normal splenic based on BGSr (powder and nanoparticles) were also studied and it was observed that the BGSr powder showed no effects on activated splenic cells which did not cause any acute cytotoxicity or lysis to RBCs which conclude that BGSr is an inert material which did not cause any hepatic cytotoxicity.