Abstract
Sulfonamide-bearing compounds posses many types of biological activities and have been recently reported to show substantial antitumor activity in vitro and/or in vivo. There are a variety of mechanisms for the anticancer activity, and the most prominent mechanism is the inhibition of carbonic anhydrase isozymes. This work reports the synthesis of some new quinoline, pyrimido[4,5-b] quinoline and 3,1-oxazinoquinoline derivatives bearing a sulfonamide moiety. All the newly synthesized compounds were evaluated for their in vitro anticancer activity against Ehrlich ascites carcinoma cells. Compounds 10, 13, and 26 were the most active compounds with IC(50) values of 6.1 mu M, 6.8 mu M, and 6.4 mu M, respectively, and exhibited better activities than the reference drug doxorubicin (IC(50) = 68.1 mu M).