Abstract
DThis study was designed to ascertain possible synergistic and antagonistic effect of simvastatin on voriconazole antimicrobial activity in presence of current quinolones. Total eight groups were used. Antibiotic, antifungal and statin interactions were noticed by using "well diffusion" method. Significant difference was observed between voriconazole + moxifloxacin (VM) and voriconazole + levofloxacin + simvastatin (VLS) groups showed significance P value = 0.0076. The percentage shift in zone of inhibition (of voriconazole zone diameter) was, positive control = 100%, voriconazole + simvastatin (VS) = 116%, voriconazole + ciprofloxacin (VC) = 104%, VM = 84%, voriconazole + levofloxacin (VL) = 90%, voriconazole + ciprofloxacin + simvastatin (VCS) = 90%, voriconazole + moxifloxacin + simvastatin (VMS) = 89%, VLS = 118%. Levofloxacin, voriconazole and simvastatin have synergistic effect on zone of inhibition against Aspergillus fumigatus. Simvastatin alone increased the zone of inhibition in presence of voriconazole. However, ciprofloxacin and moxifloxacin also showed some decrease in presence of voriconazole. However ciprofloxacin and moxifloxacin also showed some decrease in the zone of inhibition in presence of Voriconazole against Aspergillus fumigatus once simvastatin was added.