Abstract
In this study, 10 essential oils (EOs), from nine plants (
,
,
,
,
,
,
,
, and
) were assessed for their antimicrobial, antiaging and antiproliferative properties. While only
,
(MIC: 0.50 mg/mL) and
(MIC: 2 mg/mL) EOs showed activity against
, all EOs except S. samarangense EO demonstrated activity against
(MIC: 0.125-0.50 mg/mL). The EOs were either fungistatic or fungicidal against one or both tested Candida species with minimum inhibitory/fungicidal concentrations of 0.016-32 mg/mL. The EOs also inhibited one or both key enzymes involved in skin aging, elastase and collagenase (IC
: 89.22-459.2 µg/mL; 0.17-0.18 mg/mL, respectively). Turmerone, previously identified in the
EO, showed the highest binding affinity with the enzymes (binding energy: -5.11 and -6.64 kcal/mol). Only
leaf,
,
,
,
, and
EOs were cytotoxic to the human malignant melanoma cells, UCT-MEL1 (IC
: 88.91-277.25 µg/mL). All the EOs, except
EO, were also cytotoxic to the human keratinocytes non-tumorigenic cells, HaCat (IC
: 33.73-250.90 µg/mL). Altogether, some interesting therapeutic properties of the EOs of pharmacological/cosmeceutical interests were observed, which warrants further investigations.