Abstract
Metal complexes are important resource for the generation of chemical diversity in the search for novel therapeutic and diagnostic agents, especially in the area of anticancer drug development. It was of our interest to investigate the in vivo antitumor activity of Bis (4-bromobenzaldehyde-4-iminacetophenone) tetraaquochromium (III) Sulphate (BBIA-Cr) complex against Ehrlich ascites carcinoma cells induced in male albino mice. 125 Male Swiss albino mice were equally divided into five main groups: Normal, EAC, vehicle, BBIA-Cr and treated groups. Results indicated that treatment with BBIA-Cr had prevented the accumulation of ascetic fluid and consequently decreased cell viability, which in turn resulted in increased life span of tumor bearing mice. Intraperitoneal injection of BBIA-Cr to EAC inoculated mice had significantly improved hematological parameters compared to non-treated EAC group. These entire indicate that BBIA-Cr complex exhibited antitumor activity against EAC induced in mice.