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In Vivo Efficacy of Humanized WCK 5222 (Cefepime-Zidebactam) Exposures against Carbapenem-Resistant Acinetobacter baumannii in the Neutropenic Thigh Model
Journal article   Open access  Peer reviewed

In Vivo Efficacy of Humanized WCK 5222 (Cefepime-Zidebactam) Exposures against Carbapenem-Resistant Acinetobacter baumannii in the Neutropenic Thigh Model

Safa S Almarzoky Abuhussain, Lindsay M Avery, Kamilia Abdelraouf and David P Nicolau
Antimicrobial agents and chemotherapy, Vol.63(1)
01/01/2019
DOI: https://doi.org/10.1128/AAC.01931-18
PMCID: PMC6325183
PMID: 30373797

Abstract

Acinetobacter baumannii - drug effects Acinetobacter baumannii - enzymology Acinetobacter baumannii - genetics Acinetobacter baumannii - growth & development Acinetobacter Infections - drug therapy Acinetobacter Infections - microbiology Acinetobacter Infections - pathology Animals Anti-Bacterial Agents - pharmacology Azabicyclo Compounds - pharmacology Bacterial Load - drug effects beta-Lactam Resistance - drug effects beta-Lactam Resistance - genetics beta-Lactamases - genetics beta-Lactamases - metabolism Carbapenems - pharmacology Cefepime - pharmacology Cephalosporins - pharmacology Colony Count, Microbial Cyclooctanes - pharmacology Disease Models, Animal Female Gene Expression Humans Mice Mice, Inbred ICR Microbial Sensitivity Tests Neutropenia - drug therapy Neutropenia - microbiology Neutropenia - pathology Piperidines - pharmacology Thigh - microbiology Treatment Outcome
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https://doi.org/10.1128/AAC.01931-18View
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