Abstract
The relative bioavailability of a bioadhesive containing, directly compressed, tablet formulation against the commercial indomethacin capsules "Indocid, MSD" has been investigated in dogs. The tablets showed a prolongation of the time to reach maximum concentration to 3 hours compared to 2 hours in capsules. They also showed 39% and 184% increase in maximum and minimum plasma concentration, respectively. The relative bioavailability of the tablets is 152% compared to capsules where the tablets showed a mean area under the plasma concentration-time curve of 26 ug.hr/ml compared to 17 ug.hr/ml for capsules.