Abstract
The 20th century observation of increasing comprehensive load of cancer, advanced cancer prevention strategies, creative hypotheses and control procedures by research communities are being traversed and stimulated in multiple facets. Inference of genetically modified nonpathogenic and natural bacterial species as potential anti-tumor agents is one such original perspective. Live, genetically modified nonpathogenic or attenuated bacterial species are able to form biofilms by multiplying selectively or nonselectively on cancer cells, which will lead to metastasis disruption. However, the appearance of gene directed prodrug therapy and recombinant DNA technology has invigorated the notice in range of applications employing bacteria and bacterial therapy and have been carried out. The most possible and promising upcoming strategies are bacteria mediated cancer treatment. Significant efficacy in preclinical studies have been demonstrated and some are presently under clinical investigation. The theorem is that cancer metastasis can either be blunt by opponent bacterial biofilm infection or serve as model vectors for delivering therapeutic proteins to tumors or generation of the new phenotypes during the SOS reaction incite by anticancer drugs. (C) 2017 Elsevier Ltd. All rights reserved.