Abstract
The present study has been aimed to evaluate the anti-inflammatory property of P. guajava leaves by in-vitro using HRBC membrane stabilization method and anti-aging potential by in-silico method using AutoDock. The anti-inflammatory and anti-aging activity of leaf extracts of Psidium guajava collected from North Chennai region, India were evaluated in the present study. The in-vitro method showed significant anti-inflammatory property and anti-aging potential by binding with the target. The maximum membrane stabilization depicting the anti-inflammatory activity of P. guajava extracts was found to be 50% at a dose of 750 ug/ml. The effect of ascorbic acid from P. guajava leaves extract for preventing skin aging showing minimal binding energy for binding ligand (ascorbic acid) with the target protein (AP-1) was observed.