Abstract
Bicyclic heterocyclic compounds viz. benzothiazoles are key components of deoxyribonucleic acid (DNA) molecules and participate directly in the encoding of genetic information. Benzothiazoles, therefore, represent a potent and selective class of antitumor compounds. The design and synthesis of chiral antitumor chemotherapeutic agents of Cu(II) and Zn(II), L- and -D benzothiazole Schiff base-valine complexes la 82 b and 2a 82 b, respectively were carried out and thoroughly characterized by spectroscopic and analytical techniques. Interaction of la and b and 2a and b with CT DNA by employing UV-vis, florescence, circular dichroic methods and cleavage studies of la with pBR322 plasmid, molecular docking were done in order to demonstrate their enantiomeric disposition toward the molecular drug target DNA. Interestingly, these studies unambiguously demonstrated the greater potency of L-enantiomer in comparison to D-enantiomer. (C) 2014 Elsevier B.V. All rights reserved.