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In vitro antimalarial and xanthine oxidase inhibition of 2-Aminoanthraquinone
Journal article   Peer reviewed

In vitro antimalarial and xanthine oxidase inhibition of 2-Aminoanthraquinone

Abdur Rauf, Rehan Khan, Haroon Khan, Noor Jehan, Mohammad Akram, Zarka Ahmad, Naveed Muhammad, Umar Farooq and Ajmal Khan
Pakistan journal of pharmaceutical sciences, Vol.29(2), pp.429-432
03/2016
PMID: 27087090

Abstract

Animals Anthraquinones - pharmacology Antimalarials - pharmacology Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Humans Molecular Structure Plasmodium - drug effects Plasmodium - growth & development Xanthine Oxidase - antagonists & inhibitors Xanthine Oxidase - metabolism
In the present research study 2-Aminoanthraquinone were scrutinized for their antimalarial and Xanthine oxidase inhibitor potential. It demonstrated marked concentration dependent antimalarial activity with maximum effect of 89.06% and with IC50 of 34.17 µM. Regarding Xanthine oxidase inhibitor activity, it evoked significant effect with 57.45% activity with IC50 value of 81.57.19 μM. In conclusion, 2-Aminoanthraquinone showed potent antimalarial and xanthine oxidase inhibitory activity.

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