Abstract
Trichomonas vaginalis, which affects at least 170 million individuals globally, may increase the risk of transmission of HIV and predispose pregnant women to premature rupture of membranes and early labour. Whole plants of Xanthium brasilicum and Argemone mexicana were extracted by methanol, chloroform and water and then prepared in different concentrations in order to be examined for their trichomonacidal activities in vitro. Their activity was compared with metronidazole using strains of Trichomonas vaginalis freshly isolated from patients. Methanolic extracts of Xanthium brasilicum exhibit 100% mortality at concentration 500 [micro]g/ mL after 192 hours, this was compared with metrondizole powder which gave 98.5% mortality at concentration 312.5 [micro]g/mL at the same time, while the chloroform extracts gave mortality 100 % at 1000 [micro]g/mL after 216 hours, mean while, the Water extracts gave 100% mortality at 1000 [micro]g/ml after 192 hours. Water extract of Argemone mexicana gave 100% mortality 1000 [micro]g/ml after 192 hours, while the chloroform and methanol extracts 1000 [micro]g/ml gave 100 % mortality after 216 and 192 hours respectively. Key Word: Trichomonas vaginalis, Xanthium brasilicum, Argemone mexicana