Abstract
Six organotin(IV) compounds with general formulae R3SnL, R = Me (2), Ph (6), R2SnL2, R = Me (1), Et (3), n-Oct (5), [((R2SnL)(2)O)(2)], R = Bu (4). L = 6-nitropiperonylate, have been prepared. The newly synthesized compounds have been characterized by elemental analysis, FT-IR and multinuclear NMR (H-1, C-13 and Sn-119). The structure of 4 has been determined by single crystal X-ray crystallography which is triclinic with the space group P (1) over bar The crystal Structure contains centrosymmetric dimer distannoxane with planar central four-membered Sn2O2 core. The 6-nitropiperonylate ligand shows different modes of coordination with Sn, as a result the central Sn2O2 core is fused with two four-membered (Sn(1)-O(1)-Sn(2)-O(13)) and two six-membered (Sn(1)-O(13)-Sn(2)-O(8)-C(9)-O(7)) rings. The endocyclic Sn(2) is six coordinated in a skew trapezoidal bipyramidal environment while exocyclic Sn(1) is five coordinated with distorted trigonal bipyramidal geometry. The ligand acid and synthesized organotin compounds were also screened for antibacterial, antifungal, brine-shrimp lethality and potato disc antitumor activities. Results of bioassay demonstrate that organotin derivatives are in general more active than the ligand acid. (C) 2009 Elsevier Ltd. All rights reserved.