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In vitro effects of aceclofenac and its metabolites on the production by chondrocytes of inflammatory mediators
Journal article   Peer reviewed

In vitro effects of aceclofenac and its metabolites on the production by chondrocytes of inflammatory mediators

Y Henrotin, X de Leval, M Mathy-Hartet, A Mouithys-Mickalad, G Deby-Dupont, J M Dogné, J Delarge and J Y Reginster
Inflammation research : official journal of the European Histamine Research Society ... [et al.], Vol.50(8), pp.391-9
08/2001

Abstract

80 and over Adult Aged Anti-Inflammatory Agents Cells Chondrocytes Cultured Cyclooxygenase 1 Cyclooxygenase 2 Cyclooxygenase 2 Inhibitors Cyclooxygenase Inhibitors Cytokines Diclofenac Dinoprostone DNA Humans Inflammation Mediators Interleukin-1 Isoenzymes Membrane Proteins Middle Aged Nitric Oxide Nitric Oxide Synthase Nitric Oxide Synthase Type II Non-Steroidal Prostaglandin-Endoperoxide Synthases Reverse Transcriptase Polymerase Chain Reaction
To investigate the mechanisms of action underlying the anti-inflammatory action of aceclofenac in vivo, we studied in vitro the effect of aceclofenac and its main metabolite, 4'-hydroxyaceclofenac, in comparison with diclofenac, another metabolite, on cyclooxygenases activity as well as interleukin-1beta, -6 and -8, nitric oxide, and prostaglandin E2 production by human osteoarthritic and normal articular chondrocytes.

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