Abstract
Background
The current study investigates the antioxidant activity of
Acalypha indica
aerial parts and root ethanolic extracts and explore whether these extracts will stimulate fibroblasts viability and ability to migrate.
Results
Aerial parts extract exhibited higher DPPH scavenging activity compared to root extract with IC
50
of 62 µg/mL and 206 µg/mL, respectively. Both aerial parts and root extracts showed low cytotoxicity towards fibroblasts with 753 µg/mL LD
50
for aerial parts and undetected LD
50
for root extract. Additionally, aerial parts extract significantly induces fibroblasts proliferation up to 134%. Wound closure investigation showed a significant closure percentage for aerial parts compared to untreated control with 75% at 1 µg/mL and high closure percentage with 70% at 0.1 µg/mL for root extract compared to only 59% closure percentage for untreated control after 48 h of the study.
Conclusions
This study provided evidence for
A. indica
to have great wound healing potential. The finding builds the scientific background in future to utilise the high antioxidant activity of
A. indica
and its ability to stimulate fibroblasts migration and proliferation for further applications.