In vitro generation of platelets through direct conversion: first report in My Knowledge (iMK)

Shigeo Masuda; Mo Li; Juan Carlos Izpisua Belmonte

doi:10.1038/cr.2012.142

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In vitro generation of platelets through direct conversion: first report in My Knowledge (iMK)

Journal article

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In vitro generation of platelets through direct conversion: first report in My Knowledge (iMK)

Shigeo Masuda, Mo Li and Juan Carlos Izpisua Belmonte

Cell research, Vol.23(2), pp.176-178

01/02/2013

DOI: https://doi.org/10.1038/cr.2012.142

PMCID: PMC3567822

PMID: 23044804

Abstract

Research Highlight

Blood transfusion medicine requires a constant supply of platelets, which is now totally donor dependent. Recent advances in the generation of platelets in vitro through megakaryocytes (MKs) may provide protocols not only via pluripotent stem cells, including induced pluripotent stem cells (iPSCs) and embryonic stem cells (ESCs), but also via induced MKs (iMKs). For the first time, mouse and human fibroblasts are successfully transdifferentiated into iMKs by the introduction of three factors, p45NF-E2, Maf G, and Maf K.

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Title: In vitro generation of platelets through direct conversion: first report in My Knowledge (iMK)
Creators - without role: Shigeo Masuda - Salk Institute for Biological Studies
Mo Li - Salk Institute for Biological Studies
Juan Carlos Izpisua Belmonte - Salk Institute for Biological Studies
Publication Details: Cell research, Vol.23(2), pp.176-178
Publisher: Nature Publishing Group
Identifiers: 9941767108331
Academic Unit: King Abdullah University of Science & Technology
Language: English
Resource Type: Journal article