Abstract
In this study, the methanolic extract of Raphanus sativus (RSME) seeds was evaluated for its protective effect against CCl4-induced nephrotoxicity. The treatment of Swiss albino rats with intraperitoneal injections of CCl4 (1 ml/kg body weight) on alternate days for 30 days decreased the antioxidant enzymes, while lipid peroxidation and serum toxicity markers were increased. These changes were reversed in the animals receiving an oral dose of RSME (100 and 200 mg/kg body weight) along with CCl4, thus increasing the level of antioxidant enzymes and decreasing serum toxicity markers and thus ameliorating the toxic effect of CCl4. These results show that seed extract of R. sativus can reciprocate the toxic effects of CCl4 and can be used to make a chemopreventive drug.