Abstract
Aims: To explore the antifungal activity of 2,3-dimethylquinoxaline.
Study Design: A preclinical study of a compound against 10 fungal species.
Backgrounds: Severe fungal infections cause significant clinical problem and need more effort to search for new antifungals.
Methodology: We evaluated the susceptibility of 2,3-dimethylquinoxaline in vitro against a wide range of pathogenic fungi, including six Candida species, two Aspergillus species, one Cryptococcus species, and one Trichophyton species. Also, we evaluated the susceptibility of 2,3-dimethylquinoxaline in vivo against oral candidiasis using a mice model.
Results: The highest score of the minimum inhibitory concentration was 9 mu g/ml against Cryptococcus neoformans. While, the lowest score was 1125 mu g/ml against Candida tropicalis. The oral candidiasis in a mouse model was resolved using 2,3-dimethylquinoxaline 1% gel.
Conclusion: The 2,3-Dimethyquinoxaline has interesting antifungal activity. Quinoxalines in general need to be further developed as a promising antifungal candidate.