Abstract
2,5-Disubstituted -1,3,4-oxadiazoles were synthesized through one-pot Indium-catalyzed C-N bond formation/cyclisation reaction at 100 degrees C in dimethoxycthane. This methodology allows simple and efficient process for the synthesis of 2,5-disubstituted-1,3,4-oxadiazoles in good to excellent yields from readily available acylhydrazines and acid chlorides. Further, the compounds were studied for anticancer activity on MCF-7 cell line.