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Inactivation of AT1a receptor attenuates lactate accumulation and enhances cardiac performance during exercise endurance
Journal article   Peer reviewed

Inactivation of AT1a receptor attenuates lactate accumulation and enhances cardiac performance during exercise endurance

Ahmad M Alhajoj, Mahmoud S Alghamri, Roberta L Pohlman, Debora Nakamoto and Mariana Morris
Medicine and science in sports and exercise, Vol.46(5)
01/05/2014

Abstract

Analysis Cardiac output Exercise Health aspects Lactates
The study aims to evaluate the role of AT1a receptors on heart function, and exercise tolerance in response to chronic exercise using AT1a receptor deletion (AT1aKO) mice. The results indicate that mice lacking AT1a receptor exhibited improved cardiac function without myocardium hypertrophy, higher exercise endurance, and enhanced metabolic response under chronic exercise stimulation.

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