Abstract
Acute kidney injury (AKI) has been increasingly recognized as a common and serious postoperative complication. Although many studies have been conducted to investigate postoperative AKI after thoracic surgery, little is known about AKI after esophageal surgery. Thus, we conducted this study to determine the incidence and identify risk factors of postoperative AKI after esophageal cancer surgery.
A retrospective nested case-control study of patients undergoing elective esophageal cancer surgery between July 2013 and July 2016 in a single tertiary specialized cancer hospital was performed. The primary outcome was development of AKI. Conditional logistic regression analysis was performed to identify independent risk factors for AKI.
Of 2094 patients, 51 (2.4%) developed postoperative AKI after esophageal cancer surgery. In multivariate conditional logistic regression analysis, four risk factors for AKI after esophageal surgery for cancer were identified: preoperative serum creatinine level (OR 1.040; 95% CI 1.012–1.069), duration of surgery (OR 1.009; 95% CI 1.005–1.014), smoking history (OR 3.029; 95% CI 1.092–8.399) and hypertension (OR 6.422; 95% CI 2.736–15.070).
Postoperative AKI occurred in 2.4% of patients after esophageal surgery for cancer. Preoperative serum creatinine level, duration of surgery, smoking history and hypertension were independent risk factors for postoperative AKI.
•This study identified risk factors of postoperative AKI following esophageal cancer surgery.•Postoperative AKI occurred in 2.4% of patients after esophageal cancer surgery.•Risk factors were preoperative Cr, operation time, smoking history and hypertension.