Abstract
118 cases of acute pyogenic meningitis were admitted in the department of Paediatrics Liaquat Medical College, Hospitals Jamshoro/Hyderabad in one year period with prevalence of 1.57% of the total admissions. After selecting the cases on clinical ground we proceeded further to confirm the diagnosis by cerebrospinal fluid cytochemical analysis, gram staining,, culture and sensitivity and detection of the antigen of micro-organism by latex agglutination test.