Abstract
Background: MIS-C associated with Covid-19 is characterized by way of persistent fever and is often associated with a stomach ache, vomiting, diarrhea, rash, and conjunctivitis, and other mucocutaneous manifestations. Aim: This work aims to determine the clinical course, safety profile, and inflammatory markers of Multisystem Inflammatory Syndrome in Children (MIS-C) which is associated with Covid-19 children. Methodology: A systematic search was performed over different medical databases to identify Pediatrics studies, which studied the outcome of the MIS-C of Covid-19 children. We conducted a meta-analysis process on the incidence of MIS-C as a primary outcome, and on the estimated level of serum C-Reactive Protein (CRP), ferritin, and D-dimer as secondary outcomes. Six studies were identified involving 1747 children with Covid-19. Our meta-analysis process showed a pooled incidence of MIS-C in Covid-19 children of 39.8%. Concerning the secondary outcome measures, the Fixed-effects model of the meta-analysis process revealed an average estimate CRP level of 223.1 mg/dl, an average estimate ferritin level of 566.5 mg/dl, and an average estimate D-dimer level of 595.6 mg/dl, respectively. Conclusion: To conclude, Covid-19 infection is typically very mild and often asymptomatic in children. Multisystem Inflammatory Syndrome in Children (MIS-C), which is a rare complication associated with Covid-19, presenting after infection as high fever, organ dysfunction, and strongly elevated markers of inflammation.