Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2 Optimization of BX-517

Imadul Islam; Greg Brown; Mark A Polokoff; James WU; JUN Shen; Janette Walters; Elena HO; Babu Subramanyam; DAGUANG Zhu; Richard I Feldman; Damian O Arnaiz; Judi Bryant; Paul Hrvatin; Monica J Kochanny; Gary B Phillips; SHENDONG Yuan; Marc Adler; Marc Whitlow; Dao Lentz

doi:10.1016/j.bmcl.2007.05.060

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Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2 Optimization of BX-517

Journal article

Peer reviewed

Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2 Optimization of BX-517

Imadul Islam, Greg Brown, Mark A Polokoff, James WU, JUN Shen, Janette Walters, Elena HO, Babu Subramanyam, DAGUANG Zhu, Richard I Feldman, …

Bioorganic & medicinal chemistry letters, Vol.17(14), pp.3819-3825

15/07/2007

DOI: https://doi.org/10.1016/j.bmcl.2007.05.060

PMID: 17544272

Abstract

Antineoplastic agents

Biological and medical sciences

General aspects

Medical sciences

Pharmacology. Drug treatments

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Title: Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2 Optimization of BX-517
Creators - without role: Imadul Islam - Berlex Biosciences, 2600 Hilltop Dr. Richmond, CA 94804, USA
Greg Brown - Berlex Biosciences, 2600 Hilltop Dr. Richmond, CA 94804, USA
Mark A Polokoff - Berlex Biosciences, 2600 Hilltop Dr. Richmond, CA 94804, USA
James WU - Berlex Biosciences, 2600 Hilltop Dr. Richmond, CA 94804, USA
JUN Shen - Berlex Biosciences, 2600 Hilltop Dr. Richmond, CA 94804, USA
Janette Walters - Berlex Biosciences, 2600 Hilltop Dr. Richmond, CA 94804, USA
Elena HO - Berlex Biosciences, 2600 Hilltop Dr. Richmond, CA 94804, USA
Babu Subramanyam - Berlex Biosciences, 2600 Hilltop Dr. Richmond, CA 94804, USA
DAGUANG Zhu - Berlex Biosciences, 2600 Hilltop Dr. Richmond, CA 94804, USA
Richard I Feldman - Berlex Biosciences, 2600 Hilltop Dr, Richmond, CA 94804, United States
Damian O Arnaiz - Berlex Biosciences, 2600 Hilltop Dr, Richmond, CA 94804, United States
Judi Bryant - Berlex Biosciences, 2600 Hilltop Dr. Richmond, CA 94804, USA
Paul Hrvatin - Berlex Biosciences, 2600 Hilltop Dr. Richmond, CA 94804, USA
Monica J Kochanny - Berlex Biosciences, 2600 Hilltop Dr, Richmond, CA 94804, United States
Gary B Phillips - Berlex Biosciences, 2600 Hilltop Dr. Richmond, CA 94804, USA
SHENDONG Yuan - Berlex Biosciences, 2600 Hilltop Dr. Richmond, CA 94804, USA
Marc Adler - Berlex Biosciences, 2600 Hilltop Dr. Richmond, CA 94804, USA
Marc Whitlow - Berlex Biosciences, 2600 Hilltop Dr. Richmond, CA 94804, USA
Dao Lentz - Berlex Biosciences, 2600 Hilltop Dr. Richmond, CA 94804, USA
Publication Details: Bioorganic & medicinal chemistry letters, Vol.17(14), pp.3819-3825
Publisher: Elsevier
Identifiers: 9921995608331
Academic Unit: King Saud Bin Abdulaziz University for Health Sciences
Language: English
Resource Type: Journal article