Abstract
A novel efficient eco-friendly on “ionic liquid” method has been developed for the synthesis of multi-functionalized isoxazolidines through a nitrone 1,3-dipolar cycloaddition reaction. The low cost and eco-benign room temperature ionic liquid, acetylcholine iodide-ethylene glycol (ACI/EG) accelerates the formation of the desired regioselective mono-/di isoxazolidine analogues and reduced the reaction time with high level of chemical yield. Furthermore, the recyclability of ACI/EG has also been investigated.
Quaternary ammonium salt based room temperature ionic liquid, ACI/EG utilized for the synthesis of isoxazolidine heterocyclic hybrids by the addition of beta lactam fused nitrone with number of mono/bis O-allylic dipolarophiles. Exclusive regioselectivity with excellent chemical yield was achieved. [Display omitted]