Abstract
Polycystic ovary syndrome (PCOS) is endocrine system disease which affect women ages 18 to 44 where the women’s hormones are
imbalance. Recently it has been reported to occur in early age. Alteration of normal gene expression in PCOS has shown negative
effects on long-term health issues. PCOS has been the responsible factor for the infertility in women of reproductive age group. Early
diagnosis and treatment can improve the women’s health suffering from PCOS. Earlier Studies shows correlation of PCOS upon
insulin resistance with significant outcome, Current study shows the linkage between PCOS with obesity and non-obese patients. Gene
expression datasets has been downloaded from GEO (control and PCOS affected patients). Normalization of the datasets were
performed using R based on RMA and differentially expressed gene (DEG) were selected on the basis of p-value 0.05 followed by
functional annotation of selected gene using Enrich R and DAVID. The DEGs were significantly related to PCOS with obesity and
other risk factors involved in disease. The Gene Enrichment Analysis suggests alteration of genes and associated pathway in case of
obesity. Current study provides a productive groundwork for specific biomarkers identification for the accurate diagnosis and efficient
target for the treatment of PCOS.