Abstract
In this study, synthesis, biological activity and structure-activity relationships of diverse compounds are described. In general, the relationships between dipole moment and biological activities are discussed in detail. Despite progress of interdisciplinary science, the use of dipole moment values of organic compounds to understand their potent medicinal activities in various diseases remains unexplored. In contrast, it can be seen that many compounds demonstrate a direct correlation between biological activity and dipole moment. Therefore, analyzing the dipole moment values, scientists may design more potent compounds prior to their synthesis which is tedious, costly and time-consuming.
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•In this study, synthesis, biological activity and structure-activity relationships of diverse compounds are described.•In general, the relationships between dipole moment and biological activities are discussed in detail.•The use of dipole moment values of organic compounds to understand their potent activities remains unexplored.•Many compounds demonstrate a direct correlation between biological activity and dipole moment.•By analyzing the dipole moment values, scientists may design more potent compounds prior to their synthesis.