Abstract
A study of the interaction of tetradecyltrimethylammonium bromide (TTAB) and levofloxacin hemihydrate (LFH) mixtures has been studied by conductivity measurement method in aqueous medium and in the presence of inorganic electrolyte (KNO
3
and K
2
SO
4
)/urea at various temperatures (298.15−318.15 K) with typical gap of 5 K. For pure TTAB along with drug-TTAB mixture in aqueous as well as in salts/urea solution, a single critical micelle concentration (CMC) was noticed. The CMC values for LFH-TTAB mixtures in the presence of salts exhibited lower in magnitude as compared to aqueous solution. The ΔG
m
values were found to be negative in the entire cases signifying the spontaneous formation of micelles. Both ΔH
m
and ΔS
m
indicated that hydrophobic as well as electrostatic interactions were enhanced in the presence of electrolytes compared to an aqueous solution. Other thermodynamics variables such as transfer enthalpy (ΔH
m.tr
), transfer energy (ΔG
m.tr
), and transfer entropy (ΔS°
m.tr
) were evaluated and explained thoroughly.