Abstract
[M(HL)(2)] complexes (M=Co(II) (1), Ni(II) (2), and Cu(II) (3); H2L=4-hydroxybenzoic[(5-nitro-2-furanyl)methylene]hydrazide acid, nifuroxazide) were synthesized, characterized (by elemental analysis, TG, IR, UV-vis., EPR, magnetic, and conductance measurements) and tested for their antimicrobial activities. H2L is a mono-negative bidentate ligand via hydrazone N and C-O- forming intermediate complexes between tetrahedral and square-planar geometries (flattened tetrahedron, D-2d symmetry) for 1 and 2, as well as square-planar for Cu(II) complex 3. Natural bond orbital analysis revealed that the interaction of oxygen with metal ion is the main factor which determines the stability of 1-3 as the binding energy decreases with an increase in the M-O bond length. Time-dependent density functional theory calculations were carried out to understand the electronic transitions in related experimental observations. The reduction potential values of the nitro group are affected by the metal center. Ni(II) complex 2 displayed the highest activity among the tested complexes against Escherichia coli with a MIC50 value of 0.098molmL(-1) compared with 0.131 (1) and 0.117molmL(-1) (3).
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