Abstract
Investigation of the interaction of promethazine hydrochloride (PMH) with tetradecyltrimethylammonium bromide (TTAB) in attendance/nonattendance of different electrolytes (KCl and K2SO4) has been conducted by conductivity technique at different temperatures with an interval of 5.0 K. In this work, a single critical micelle concentration (CMC) was observed for the PMH + TTAB mixed system with/without electrolytes. In the occurrence of the drug (PMH), the values of CMC for surfactant (TTAB) are lower in magnitude in comparison with TTAB in water. In attendance of various electrolytes (KCl and K2SO4), the obtained CMC values for TTAB + PMH mixtures were lower in magnitude compared with their nonattendance. It indicates the favorable micellization of TTAB + PMH mixture, and the presence of electrolytes supported the earlier micellization. The obtained values of Delta G(m)(0) are negative, which indicates the spontaneous aggregation process. Different other physicochemical parameters like enthalpy change (Delta H-m(0)), entropy change (Delta S-m(0)), transfer energy (Delta G(m.tr)(0)), transfer enthalpy (Delta H-m.tr(0)), and transfer entropy (Delta S-m.tr(0)) were also calculated as well as explained thoroughly. The molar heat capacity (Delta C-m(0)), the compensation temperature (T-c), and the intrinsic enthalpy gain (Delta H-m(0*)) were also evaluated as well as explained.