Sign in
Inhibition of maturation of Rauscher leukemia virus by amino acid analogs
Journal article   Open access  Peer reviewed

Inhibition of maturation of Rauscher leukemia virus by amino acid analogs

G A Jamjoom, V L Ng and R B Arlinghaus
Journal of virology, Vol.25(1), pp.408-412
01/1978
PMCID: PMC353938
PMID: 621781

Abstract

Canavanine - pharmacology Culture Techniques p-Fluorophenylalanine - pharmacology Peptide Biosynthesis Phenylalanine - analogs & derivatives Protein Precursors - biosynthesis Protein Precursors - metabolism Rauscher Virus - drug effects Rauscher Virus - growth & development Rauscher Virus - metabolism Viral Proteins - biosynthesis Viral Proteins - metabolism Virus Replication - drug effects
Synthesis of primary precursor polyproteins of Rauscher leukemia virus (RLV) core and envelope proteins occurs in the presence of amino acid analogs canavanine and p-fluorophenylalanine, but cleavage of these precursors is severely inhibited or slowed down. After treatment with these agents, the release of characteristic virus or stable virus-like particles is greatly depressed.
url
https://doi.org/10.1128/JVI.25.1.408-412.1978View
Published (Version of record) Open

Metrics

1 Record Views

Details