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Inhibition of oncogene product enzyme activity as an approach to cancer chemoprevention. Tyrosine‐specific protein kinase inhibition by daphnoretin from Thymelaea hirsuta root
Journal article   Peer reviewed

Inhibition of oncogene product enzyme activity as an approach to cancer chemoprevention. Tyrosine‐specific protein kinase inhibition by daphnoretin from Thymelaea hirsuta root

Mohamed Abou-Karam, Nagwa S. El-Shaer and W. Thomas Shier
Phytotherapy research, Vol.12(4), pp.282-284
06/1998
DOI: https://doi.org/10.1002/(SICI)1099-1573(199806)12:4<282::AID-PTR225>3.0.CO;2-X

Abstract

cultured mammalian cells cytotoxicity daphnoretin Thymelaea hirsuta (L.) Endl Thymelaeaceae tyrosine kinase inhibition
Inhibitors of oncogene product enzyme activity were sought as a prescreen for potential cancer chemopreventive agents. Daphnoretin, a dicoumaryl ether from Thymelaea hirsuta root, inhibited the erb‐b oncogene product, the tyrosine‐specific protein kinase of human epidermal growth factor receptor (IC50 = 97.5 μM). Daphnoretin was moderately cytotoxic (IC50 = 21–114 μM) only in rapidly proliferating cultured mammalian cells. © 1998 John Wiley & Sons, Ltd.

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