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Inhibition of p300 Lysine Acetyltransferase activity by Luteolin reduces tumor growth in head and neck squamous cell carcinoma (HNSCC) xenograft mouse model
Journal article

Inhibition of p300 Lysine Acetyltransferase activity by Luteolin reduces tumor growth in head and neck squamous cell carcinoma (HNSCC) xenograft mouse model

R.B Selvi, A Swaminathan, S Chatterjee, M.K Shanmugam, F Li, G.B Ramakrishnan, K.S Siveen, A Chinnathambi, M Emam Zayed, S.A Alharbi, …
2015

Abstract

acetyl coenzyme A animal animal experiment animal model animal tissue Animals antineoplastic activity antineoplastic agent Antineoplastic Agents binding competition cancer inhibition Carcinoma cell cycle arrest cell proliferation chromatin immunoprecipitation controlled study DNA microarray down regulation drug binding site drug effects drug efficacy drug screening E1A associated p300 protein enzyme activity enzyme inhibition flow cytometry gene expression profiling gene expression regulation gene ontology Head and Neck Neoplasms head and neck squamous cell carcinoma head and neck tumor histone histone acetylation histone acetyltransferase PCAF human human cell Humans immunoblotting immunohistochemistry luteolin lysine metabolism Mice microRNA microRNA 135a microRNA 195 microRNA 215 microRNA let7C migration inhibition molecular docking Molecular Docking Simulation mouse mouse model nonhuman Oligonucleotide Array Sequence Analysis p300-CBP Transcription Factors p300-CBP-associated factor pathology promoter region protein p53 RNA processing Squamous Cell squamous cell carcinoma transcriptome treatment duration tumor xenograft unclassified drug Xenograft Model Antitumor Assays
10.18632/oncotarget.6245 Oncotarget 6 41 43806-43818

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