Abstract
Aim: The current study was undertaken to assess the protective effect of 70% methanolic. extract of Sassura lappa (costus, CT) against oxidative stress and metabolic disorders caused by deltamethrin (DM) insecticide in rats
Experimental Design: Sixty adult male albino rats were divided into six groups : G1 control group; G2, plant extract treated group (300 mg/kg); G3 (DML), rats treated with a low dose of DM (1/30 LD50; 2 mg/kg); G4 (CTDML), rats treated with costus extract one hour prior the low dose of DM administration; G5 (DMH), rats treated with a high dose of DM(1/15LD50; 4 m/kg); G6 (CTDMH), rats treated with costus extract one hour prior the high dose of DM administration.
Results: The data revealed significant reduction in hemogram parameters (RBCs, Hb and PCV) accompanied with leukocytosis in both DML and DMH groups. The result also showed that a marked elevation in the oxidative stress biomarker, MDA, with concomitant decreases in the antioxidant enzymes, namely catalase (CAT), superoxide dismutase (SOD) and glutathione-s-transferase (GST) versus control group. A marked decrease in plasma triiodothyronine (T3) of both DML and DMH rat groups, while a reduction in thyroxin (T4) was recorded in plasma of DML rat group. These results were confirmed by degenerative changes in histomorphological architecture of the thyroid gland. A remarkable elevation in plasma glucose and lipid profile (total cholesterol, triglycerides, LDL-C and HDL-C) was observed in both DM intoxicated groups. Administration of costus extract successfully could mitigate the toxic impact of DM on most of the studied parameters.
Conclusion: The present study may suggest that the protective ingestion of costus extract could alleviate the oxidative stress as well as the metabolic and thyroid disorders induced in rats under the effect of DM toxicity