Abstract
Glucose-6-phosphate (G6P) as a ligand (formulated as LH-) was reacted with V(III), Ru(III), Au(III), and Se(IV) ions. The structures of the obtained complexes were characterized by IR, H-1 and C-13 NMR, UV-Vis., molar conductance, elemental, and thermal techniques. The antibacterial activity of the complexes towards two Gram-positive and two Gram-negative bacteria were screened in vitro. Furthermore, the cytotoxicity of the Au(III) complex against two different human cancer cell lines was assessed in vitro by the MTT-based cell technique. The spectral, and analytical data suggests that G6P acts as a bidentate ligand coordinating by both oxygen atoms of the phosphate group. This forms a square planar geometry with Au(III) and Se(IV) ions and a octahedral geometry with V(III) and Ru(III) ions. Interestingly, the cytotoxic effect of Au(III) complex towards HepG2 and MCF-7 cell lines was greater than that of the free ligand by approximately 80- and 45-fold, respectively. (C) 2019 Elsevier B.V. All rights reserved.