Abstract
Herein, the construction and the electroanalytical applications of novel ticagrelor (TIC) voltammetric sensors were described. Integration of the working carbon paste electrodes with zeolite nanostructures showed a proper electrocatalytic activity toward oxidation of the TIC molecule. At the optimum measuring conditions, TIC showed an irreversible oxidation peak at 0.954 V with an assumed diffusion-reaction mechanism. Based on the electrochemical behavior at different pH and the scan rate values, the electrode reaction takes place through oxidation of the N Enamine of the ticagrelor moiety with the participation of one electron and one proton in agreement with the molecular orbital calculations. Calibration curves showed improved linearity (r = 0.9998) within the TIC concentration ranging from 8.8 to 1665 ng mL(-1) with LOD and LOQ values of 2.5 and 7.5 ng mL(-1), respectively. The introduced TIC voltammetric sensor exhibited improved performance with high measurement reproducibility and prolonged operational lifetime. The cited ZY/CPEs sensors were capable of simultaneous voltammetric determination of TIC in the existence of its degradation outcomes and expected interferents. The proposed voltammetric approach was suggested for the sensitive determination of ticagrelor in biological fluids and pharmaceutical samples with good recovery values in agreement with the spectrophotometric measurements.