Abstract
Background: Molybdenum hydroxylases have been implicated as key oxidative enzymes in some diseases.
Methods: Twenty 2-(substituted-thio)-quinazolin-4-one derivatives recently synthesized in our laboratory were examined for their inhibitory activity toward molybdenum hydroxylases.
Results and conclusion: The tested quinazolines inhibited both xanthine oxidase and aldehyde oxidase enzymes in a competitive pattern with Ki values range of 66-753 mu M. Pharmacophore prediction methodology was used to study the structure requirements of those inhibitors. (C) 2015 Future University. Production and hosting by Elsevier B.V.