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Intramolecularly stapled amphipathic peptides via a boron-sugar interaction
Journal article   Peer reviewed

Intramolecularly stapled amphipathic peptides via a boron-sugar interaction

Monika Kijewska, Angelika Czerwinska, Samah Al-Harthi, Grzegorz Wolczanski, Mateusz Waliczek, Abdul-Hamid Emwas, Mariusz Jaremko, Lukasz Jaremko, Piotr Stefanowicz and Zbigniew Szewczuk
Chemical communications (Cambridge, England), Vol.56(62), pp.8814-8817
11/08/2020
PMID: 32627786

Abstract

Chemistry Chemistry, Multidisciplinary Physical Sciences Science & Technology
Amadori products (deoxyfructosyllysine derivatives) that can selectively interact with phenylboronic acids and borate ions were synthesized. The intramolecular interactions between the fructosyl moiety and phenylboronic acid incorporated into various positions of the peptide chain were investigated using high-resolution mass spectrometry (HR-MS), circular dichroism (CD), and nuclear magnetic resonance (NMR).

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