Abstract
Background and aim: Anxiety has an effect on the common regular living of a human as it causes fatigue and restlessness. In the current study, an effort was undertaken to investigate the anti-anxiety behavior of male albino by the treatment of Avocado Powder and Juice in vivo. Methods: Avocado Powder 10 % (AP1) and 15 % (AP2) substituted from the diet and Avocado Juice 100 mL/kg (AJ1) and150ml/kg body weight (AJ2) rat over control rats. Results: The oral intake of Avocado powder and Juice caused a significant decrease in the body weight gain, daily feed intake, and feed efficiency ratio (FER) in all experimental groups tested as compared to control. Also, the activity of the antioxidant enzymes like SOD, GST, GPX, and Catalase is not much influenced by the intake of avocado fruit. This significant result has confirmed the effectiveness of this fruit for the treatment of anxiety. The anti-anxiety effect of the avocado fruit was tested by exploring the behavioral changes tests in experimental rats. All the experiments conducted showed that the intake of dose AP2 and AJ2 has significantly decreased the number of head dips and cage crossing and increased the time spent in light side in light-dark transition box test, and increased time spent in open arm in elevated plus maze test. Conclusions: This result proved that the avocado fruit as powder then as juice have an anxiolytic effects and will be a better alternative for people with an anxiety disorder. (C) 2022 The Author(s). Published by Elsevier B.V. on behalf of King Saud University.