Investigation of 5'-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents

Anastasia L Khandazhinskaya; Elena S Matyugina; Pavel N Solyev; Maggie Wilkinson; Karen W Buckheit; Robert W Buckheit, Jr; Larisa N Chernousova; Tatiana G Smirnova; Sofya N Andreevskaya; Khalid J Alzahrani; Manal J Natto; Sergey N Kochetkov; Harry P de Koning; Katherine L Seley-Radtke

doi:10.3390/molecules24193433

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Investigation of 5'-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents

Journal article

Open access

Peer reviewed

Investigation of 5'-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents

Anastasia L Khandazhinskaya, Elena S Matyugina, Pavel N Solyev, Maggie Wilkinson, Karen W Buckheit, Robert W Buckheit, Jr, Larisa N Chernousova, Tatiana G Smirnova, Sofya N Andreevskaya, Khalid J Alzahrani, …

Molecules (Basel, Switzerland), Vol.24(19), p.3433

21/09/2019

DOI: https://doi.org/10.3390/molecules24193433

PMCID: PMC6804079

PMID: 31546633

Abstract

Anti-Bacterial Agents - chemistry

Anti-Bacterial Agents - pharmacology

Antiprotozoal Agents - chemistry

Antiprotozoal Agents - pharmacology

Molecular Structure

Mycobacterium tuberculosis - drug effects

Nucleosides - analogs & derivatives

Nucleosides - pharmacology

Structure-Activity Relationship

Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial therapies. Recent results from our laboratories from two structurally related scaffolds have shown promising activity against both and several parasitic strains. As a result, a small structure activity relationship study was designed to further probe their activity and potential. Their synthesis and the results of the subsequent biological activity are reported herein.

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Title: Investigation of 5'-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents
Creators - without role: Anastasia L Khandazhinskaya - Engelhardt Institute of Molecular Biology
Elena S Matyugina - Engelhardt Institute of Molecular Biology
Pavel N Solyev - Engelhardt Institute of Molecular Biology
Maggie Wilkinson - ImQuest BioSciences
Karen W Buckheit - ImQuest BioSciences
Robert W Buckheit, Jr - ImQuest BioSciences
Larisa N Chernousova - Central Scientific Research Institute of Tuberculosis Russian Academy of Medical Sciences
Tatiana G Smirnova - Central Scientific Research Institute of Tuberculosis Russian Academy of Medical Sciences
Sofya N Andreevskaya - Central Scientific Research Institute of Tuberculosis Russian Academy of Medical Sciences
Khalid J Alzahrani - University of Glasgow
Manal J Natto - University of Glasgow
Sergey N Kochetkov - Engelhardt Institute of Molecular Biology
Harry P de Koning - University of Glasgow
Katherine L Seley-Radtke - University of Maryland, Baltimore County
Publication Details: Molecules (Basel, Switzerland), Vol.24(19), p.3433
Grant note: S8306 / Government of Saudi Arabia 18-29-08010 / Russian Foundation for Basic Research no number / Taif University
Identifiers: 9911084208331
Academic Unit: Taif University
Language: English
Resource Type: Journal article