Abstract
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•High-fat diet and streptozotocin cause apoptosis, inflammation and oxidative stress in kidney.•Green coffee inhibits HFD/STZ-induced nephrotoxicity in rats.•Green coffee has antioxidant, antiinflammatory and antiapoptotic activities.
Green coffee consumption has been stated to have a converse association with type 2 diabetes and metabolic syndrome. Hence, we assessed changes produced by the administration of different doses of green coffee on biomarkers related to renal and antioxidant systems. The study was carried out on 42 diabetic male albino rats; a high-fat diet (HFD) and a single dose of streptozotocin (STZ; 35 mg kg−1) were utilized for model induction. Diabetic rats were received green coffee water extract (GCWE; 50 and 100 mg kg−1) daily for 28 days. GCWE caused a remarkable recovery of kidney weight, kidney function, and aldosterone level, particularly. Proapoptotic, antiapoptotic and inflammatory markers were significantly improved and showing a great retain to their normal levels specifically in GCWE-treated groups. Also, a marked improvement in the antioxidants defense system was noted. GCWE has a great protective influence on kidney injury of HFD/STZ‐induced diabetic rats.