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Iodine-induced Oxidative Cyclisation of N-Acyl Amidines: A Rapid Synthesis of 3,5-Disubstituted-1,2,4-Oxadiazoles
Journal article   Peer reviewed

Iodine-induced Oxidative Cyclisation of N-Acyl Amidines: A Rapid Synthesis of 3,5-Disubstituted-1,2,4-Oxadiazoles

Mohammad Asad, Puneet K. Gupta, Subodh K. Jaiswal and Kanchan Hajela
ChemistrySelect (Weinheim), Vol.1(15), pp.4753-4757
16/09/2016
DOI: https://doi.org/10.1002/slct.201601194

Abstract

Chemistry Chemistry, Multidisciplinary Physical Sciences Science & Technology
A rapid and efficient metal-free synthesis of 3,5-disubstituted1,2,4-oxadiazoles has been developed via iodine-induced oxidative cyclisation of N-acyl amidines. This eco-friendly approach allows wide functional group tolerance and results in the direct access of highly diversified 1,2,4-oxadiazoles in 59-94% yields.

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