Abstract
H-bonding organocatalysis using (thio) urea and amine has been very successful. Ionic H-bonding catalysis, especially in polymerizations, has scarcely been explored. Here we disclose guanidinium hexahydro-2H-pyrimido[1,2-a] pyrimidin-1-ium [(HppH(2))(+)] as a representative ionic H-bond donor (IHBD), combined with tertiary amines as H-bond acceptors (HBA), promoted fast ring-opening polymerization (ROP) of L-lactide (LLA). The positively charged IHBD guanidinium exhibits exceptional activating ability towards monomer LLA. Its partnership with (-)-sparteine demonstrates excellent IHBD-HBA binary catalysis in the ROP of LLA, which featured conversions up to 97%, predicted molecular weights (from 2550 to 17 900 g mol(-1)), narrow dispersities (D <= 1.12), and short reaction times of 30 to 180 minutes. A bifunctional synergistic activation mechanism by (HppH2)+ and (-)-sparteine is proposed, and is supported by NMR measurements. The controlled/living nature of the ROP is confirmed by kinetics and chain extension experiments. H-1 NMR, SEC, and MALDI-ToF MS analyses strongly indicate that the obtained poly(L-lactide) s were exactly the designated ones. The successful synthesis of well-defined poly(trimethylene carbonate)- block-poly(L-lactide) verifies that the catalytic ROPs were of a controlled/living nature, and suggests that the IHBD-HBA binary catalysis system is generally applicable.