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Iridium-Catalyzed Enantioselective Hydroarylation of Alkenes through C-H bond Activation: Experiment and Computation
Journal article   Peer reviewed

Iridium-Catalyzed Enantioselective Hydroarylation of Alkenes through C-H bond Activation: Experiment and Computation

Chemistry : a European journal, Vol.26(37), pp.8308-8313
02/07/2020
PMID: 32301132

Abstract

Chemistry Chemistry, Multidisciplinary Physical Sciences Science & Technology
A new catalytic enantioselective hydroarylation of unactivated olefins is developed that provides rapid access to functionalized chiral dihydrobenzofurans with good yields and excellent enantioselectivities. Simple aromatic ketones or amides act as a directing group allowing the regioselective reaction at the more hinderedorthoposition. Tertiary benzylic stereocenters are obtained directly under mild reaction conditions and with complete atom economy from readily available starting materials.

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