Abstract
The present work accomplished with the aim of examination of anti-dermatophytic efficiency of Streptomyces isolates against dermatophytic fungi from mangrove estuary area of Tamil Nadu. Five hundred and six actinomycete isolates were retrieved from the sediment soil samples in Manakudi mangrove estuary, south west coast of Tamil Nadu, India. Among 506, 138 isolated were identified and categorized based on their structural similarity and cultural conditions. Selected actinomycete strains were screened for anti-dermatopytic fungal activity by cross streak and agar well diffusion methods. The cultural, biochemical and molecular features of the 10 antagonistic isolates were belongs to Streptomyces species (60%) and other non-Streptomyces (40%) Among, Streptomyces sp. ACT2 strains exhibited significant activity against selected dermatophytes. The most promising Streptomyces sp. ACT2 (GQ478247) was identified and analyzed further of their bioactive compounds. The anti-dermatophytic compounds were identified as bahamaolides and polyenepolyol from the active fraction ADF4 by GC–MS analysis.