Abstract
New lupeol long-chain alkanoic ester 1 and lupeol beta-hydroxy fatty acid esters 2c,d (laevigatins I and II) in a mixture with the previously isolated procrims a and b (2a,b) were isolated together with lupeol 3 and lupeol acetate 4 from the latex of Periploca laevigata collected in Tunisia. Their structures were elucidated by extensive spectroscopic methods including 1D (H-1, C-13 and DEPT 135), 2D-NMR experiments, (H-1-H-1 COSY and NOESY), EI-MS, MALDI-TOF and GC analysis. Anti-acetylcholinesterase activity of most isolated compounds was evaluated and showed that lupeol (3) was the best inhibitor of AChE. (C) 2013 King Saud University. Production and hosting by Elsevier B.V.