Abstract
The Covid-19 pandemics caused by SARS-CoV-19, and the inadequacy of targeted medications, compelled scientists to seek new antiviral drugs. We present our current understanding of plant extracts containing polyphenols that inhibit Covid-19. Natural phytochemicals (polyphenols) derived from plants have the potential to establish research using extracts and/or individual compounds in the treatment and prevention of coronavirus. The polyphenolic drugs (antivirus) capable of inhibiting the coronavirus protein, that are vital for infection and virus replication. The benefit of phytochemicals is that they promote patient well-being while causing minimal side effects. To understand the antiviral behavior of isolated phytochemicals 1–6, various molecular descriptors, molecular electrostatic potential (MEP), and frontier molecular orbitals (FMO) were investigated. A systematic analysis of isolated phytochemicals was accomplished then molecular descriptors, docking score, active sites, and FMOs energies were compared to the commonly used drugs recently to treat COVID19, namely favipiravir, remdesivir dexamethasone and hydroxychloroquine. Using a molecular docking technique, we demonstrate for the first time that these plant phytochemicals can be inhibited by the core protease (6LU7) protein of COVID19.