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Isolation of the Pyrrolizidine Alkaloid Intermedine-N-oxide from Cerinthe glabra and ab initio Calculation of its C-13 NMR Shifts
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Isolation of the Pyrrolizidine Alkaloid Intermedine-N-oxide from Cerinthe glabra and ab initio Calculation of its C-13 NMR Shifts

Markus Luber, Arafa Musa, Hazem A. Kadry and Franz Bracher
Zeitschrift für Naturforschung. B, A journal of chemical sciences, Vol.67(5), pp.411-416
01/05/2012

Abstract

Chemistry Chemistry, Inorganic & Nuclear Chemistry, Organic Physical Sciences Science & Technology
The pyrrolizidine alkaloid intermedine-N-oxide was isolated from Cerinthe glabra for the first time. Due to the questionable assignments of NMR signals of this compound in previous literature reports ab initio calculations of the C-13 NMR values based on the CIAO approach, using HF and B3LYP levels of theory and the four basis sets 6-31G(d), 6-311G(d), 6-31G(d,p), and 6-311G(d,p) were performed. The assignments obtained this way are in very good accordance with the experimental values.
url
https://doi.org/10.5560/ZNB.2012-0030View
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